Levorphanol
Systematic ( IUPAC) name
17-methylmorphinan-3-ol
Identifiers
CAS number	77-07-6
ATC code	?
PubChem	5359272
DrugBank	APRD00764
Chemical data
Formula	C17 H23 N O
Mol. mass	257.371 g/mol
SMILES	search in eMolecules, PubChem
Physical data
Melt. point	23 °C (73 °F)
Pharmacokinetic data
Bioavailability	?
Protein binding	40%
Metabolism	?
Half life	11-16 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	C ( US )
Legal status	Schedule II ( US )
Routes	oral, intravenous, intramuscular, subcutaneous

Levorphanol (Dromoran) is an opioid medication used to treat severe pain. The medication has a known abuse potential. In addition to acting on opioid receptors, the O-methyl derivative of its dextrorotory isomer, dextromethorphan, acts as an NMDA receptor antagonist. ^[1] Typical doses include 2 mg by mouth or subcutaneous injection every 6 to 8 hours.

Levorphanol has affinity to μ, κ, and δ opioid receptors and lacks complete cross-tolerance with morphine.

It is chemically related to dextromethorphan, an antitussive which is not an analgesic. Dextromethorphan is a salt of the methyl ether dextrorotatory isomer of levorphanol.

Notes

Donate to Wikimedia